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KMID : 0378019860290110119
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New Medical Journal
1986 Volume.29 No. 11 p.119 ~ p.128
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Clinical Evaluation of Enoxacin (Flumark^(®)) in the treatment of E.N.T. field infection
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Abstract
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Enoxacin, a newly developed pyridone-carboxylic acid derivertive, was an oral antimicrobial agent synthesized in Japan. It was shown that this new agent possessed a broad antimicrobial spectrum covering gram-positive and gram-negative bacteria.
Enoxacin was effective in respiratory tract, urinary tract, skin, biliary tract, gastrointestinal and E.N.T. field infection. So we had administered Enoxacin orally to 30 patients with E.N.T. field infection for evaluation of its clinical efficacy and side effects. The results were as follows.
1) The mean duration of therapy was 10.3 days.
2) The clinical efficacy of therapy was remarkably effective in 6 cases, effective in 19 cases and ineffective in 5 cases.
3) In Vitro, Enoxacin was bacteriologically effective in all strains except 2 cases of Pseudomonas aeruginosa.
4) The side effects were mild gastro-intestinal symptoms and generalized malaise in 4 (13.3%) of 30 cases.
5) There were no significant changes of laboratory findings before and after administration of Enoxacin.
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